کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1317676 | 1499467 | 2013 | 5 صفحه PDF | دانلود رایگان |

A copper(II) complex with the non-steroidal anti-inflammatory drug (NSAID) diclofenac has been for the first time synthesized and characterized without any co-organic ligand. Its biological activity against four human cell lines underlined a higher activity of the monomeric complex than the parent molecule in the case of tumoral cell lines. A ternary Cu-diclofenac-albumin complex was suspected to be the reactive species in biological medium.
A copper(II) complex with the non-steroidal anti-inflammatory drug (NSAID) diclofenac has been for the first time synthesized and characterized without any co-organic ligand. Its biological activity against four human cell lines underlined a higher activity of the monomeric complex than the parent molecule in the case of tumoral cell lines.Figure optionsDownload as PowerPoint slideHighlights
► Novel copper(II) complex containing the non-steroidal anti-inflammatory drug diclofenac was synthesized and characterized.
► The complex was obtained as a mononuclear species without co-organic ligand.
► The monomeric complex showed a significant biological activity against human cell lines.
► The complex underlined a higher activity than the parent molecule in the case of tumoral cell lines.
Journal: Journal of Inorganic Biochemistry - Volume 120, March 2013, Pages 39–43