کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1317676 1499467 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A novel copper(II) mononuclear complex with the non-steroidal anti-inflammatory drug diclofenac: Structural characterization and biological activity
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
A novel copper(II) mononuclear complex with the non-steroidal anti-inflammatory drug diclofenac: Structural characterization and biological activity
چکیده انگلیسی

A copper(II) complex with the non-steroidal anti-inflammatory drug (NSAID) diclofenac has been for the first time synthesized and characterized without any co-organic ligand. Its biological activity against four human cell lines underlined a higher activity of the monomeric complex than the parent molecule in the case of tumoral cell lines. A ternary Cu-diclofenac-albumin complex was suspected to be the reactive species in biological medium.

A copper(II) complex with the non-steroidal anti-inflammatory drug (NSAID) diclofenac has been for the first time synthesized and characterized without any co-organic ligand. Its biological activity against four human cell lines underlined a higher activity of the monomeric complex than the parent molecule in the case of tumoral cell lines.Figure optionsDownload as PowerPoint slideHighlights
► Novel copper(II) complex containing the non-steroidal anti-inflammatory drug diclofenac was synthesized and characterized.
► The complex was obtained as a mononuclear species without co-organic ligand.
► The monomeric complex showed a significant biological activity against human cell lines.
► The complex underlined a higher activity than the parent molecule in the case of tumoral cell lines.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Inorganic Biochemistry - Volume 120, March 2013, Pages 39–43
نویسندگان
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