کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1317750 1499476 2012 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Coordination chemistry and solution structure of Fe(II)-peplomycin. Two possible coordination geometries
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
Coordination chemistry and solution structure of Fe(II)-peplomycin. Two possible coordination geometries
چکیده انگلیسی

The solution structure of Fe(II)-peplomycin was determined from NMR data collected for this molecule. As found previously for Fe(II)- and Co(II)-bound bleomycin; the coordination sphere of the metal is composed of the primary and secondary amines in β-aminoalanine, the pyrimidine and imidazole rings in the pyrimidinylpropionamide, and β-hydroxyhistidine moieties, respectively, the amine nitrogen in β-hydroxyhistidine, and either the carbamoyl group in mannose or a solvent molecule. The two most discussed coordination geometries for the aforementioned ligands in metallo-bleomycins have been tested against the NMR data generated for Fe(II)-peplomycin. The interpretation of the experimental evidence obtained through molecular dynamics indicates that both geometries are equally likely in solution for this compound in the absence of DNA, but arguments are offered to explain why one of these geometries is preferred in the presence of DNA.

The solution structure of Fe(II)-peplomycin was determined from NMR data. The two most discussed coordination geometries for metallo-bleomycins were tested against the NMR data generated for Fe(II)-peplomycin. The molecular dynamics results indicate that both geometries are equally likely in solution for this compound.Figure optionsDownload as PowerPoint slideHighlights
► The solution structure of Fe(II) bound peplomycin was derived through NMR.
► Fe(II)-peplomycin exhibits the same coordination chemistry as Fe(II)-bleomycin.
► The two more discussed coordination geometries for metallo-bleomycins were examined.
► Both geometries were found to be equally likely in solution for Fe(II)-peplomycin.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Inorganic Biochemistry - Volume 111, June 2012, Pages 50–58
نویسندگان
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