کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1317961 | 976620 | 2010 | 7 صفحه PDF | دانلود رایگان |
The synthesis and characterization of ruthenium compounds of the type [RuCl2(NO)(dppp)(L)]PF6 [dppp = 1,3-bis(diphenylphosphino)propane; L = pyridine, 4-methylpyridine, 4-phenylpyridine and dimethyl sulfoxide] are described. The complexes were characterized by elemental analysis, UV/Vis and infrared spectroscopy, cyclic voltammetry, and X-ray crystallography for the complexes with the pyridine and 4-methylpyridine ligands. In vitro evaluation of these nitrosyl complexes revealed cytotoxic activity from 7.1 to 19.0 μM against the MDA-MB-231 breast tumor cells and showed that, in this case, they are more active than the reference metallodrug cisplatin. The 1,3-bis(diphenylphosphino)propane and the N-heterocyclic ligands alone failed to show cytotoxic activities at the concentrations tested (maximum concentration utilized = 200 μM).
The synthesis and characterization of ruthenium compounds of the type [RuCl2(NO)(dppp)(L)]PF6 [dppp = 1,3-bis(diphenylphosphino)propane; L = pyridine, 4-methylpyridine, 4-phenylpyridine and dimethyl sulfoxide] are described. In vitro evaluation of these nitrosyl complexes revealed cytotoxic activity from 7.1 to 19.0 μM against the MDA-MB-231 breast tumor cells.Figure optionsDownload as PowerPoint slide
Journal: Journal of Inorganic Biochemistry - Volume 104, Issue 5, May 2010, Pages 489–495