Preparation of ruthenium azido complex containing a Tp ligand and ruthenium-catalyzed cycloaddition of organic azides with alkynes in organic and aqueous media: Experimental and computational studies

• We reported new method for synthesis of ruthenium azido complex.
• Ruthenium azido complex catalyzes click reactions of some terminal alkynes HCCR and alkyl azide in organic and aqueous medium.
• Their structures are elucidated by IR, NMR and X-ray crystallography.
• Theoretical calculations support the proposed mechanism.

The catalytic activity of a series of ruthenium azido complexes containing Tp ligands has been evaluated for the cycloaddition of terminal alkynes and azides to give selectively 1,5-disubstituted 1,2,3-triazoles. The complex Tp(PPh3)(EtNH2)RuN3 (2, Tp = HB(pz)3, pz = pyrazolyl) was found to be an effective catalyst for the cycloaddition reactions. In the presence of complex 2, azides reacted with a range of terminal alkynes containing various functionalities to selectively produce 1,5-disubstituted 1,2,3-triazoles. Theoretical calculations support the proposed mechanism.

In the presence of complex Tp(PPh3)(EtNH2)RuN3 (2), azides reacted with a range of terminal alkynes containing various functionalities to selectively produce 1,5-disubstituted 1,2,3-triazoles. Theoretical calculations support the proposed mechanism.Figure optionsDownload as PowerPoint slide