کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1322082 | 1499861 | 2015 | 5 صفحه PDF | دانلود رایگان |
• Nickel-catalyzed cross-coupling reactions of phenol derivatives with arylboronic acids.
• In situ activation of phenols using TCT for utilization in C–C coupling reactions.
• TCT as a cheap, readily available reagent for C–O bond activation of phenolic compounds.
• Direct synthesis of biaryls from phenols using TCT as C–O bond activator.
In this study, the direct Nickel-catalyzed Suzuki–Miyaura coupling reaction of phenols and arylboronic acids via C–O bond activation using 2,4,6-trichloro-1,3,5-triazine (TCT) is described. Initially, phenols were reacted with TCT to give the corresponding 2,4,6-triaryloxy-1,3,5-triazine (TAT) products. Subsequently, arylboronic acid, base and Ni-catalyst were added to the generated aryl C–O electrophile to obtain the final biaryl product. This study represents a simple and direct method for the synthesis of biaryls from phenolic compounds using sub-stoichiometric amounts of TCT as a cheap and readily available C–O activating reagent.
An efficient method is introduced for one-pot synthesis of biaryls from phenols and arylboronic acids using activation of phenolic C–O bond by TCT reagent.Figure optionsDownload as PowerPoint slide
Journal: Journal of Organometallic Chemistry - Volume 781, 1 April 2015, Pages 6–10