Ruthenium-catalyzed coupling reaction of 2,3,5-trisubstituted furans with aryl halides through C–H bond cleavages

A variety of functionalized furans were synthesized by way of a ruthenium-catalyzed coupling reaction of 2,3,5-trisubstituted furans with aryl halides through C–H bond cleavages. The feature of the reaction was facilitative preparation of furan derivatives good functional group tolerance. All reactions gave the desired products in moderate to good yields (56–89%) in the presences of [RuCl2(p-cymene)] and K2CO3 in NMP at 120 °C.

A highly efficient method for synthesis of polysubstituted furans derivatives has been developed via Ru-catalyzed coupling reaction of 2,3,5-trisubstituted furans with aryl halides. This coupling reaction of 2,3,5-trisubstituted furans took place with aryl iodides or aryl bromides to afford a range of fran in moderate to excellent yields in the presence of [RuCl2(p-cymene)]2 and K2CO3 in NMP for 18 h.Figure optionsDownload as PowerPoint slideHighlights
► Ru-catalyzed arylation of furans with aryl halides formed aryl–aryl bond.
► Develop an efficient method for the synthesis of polysubstituted furans.
► Substituted aryl iodides and aryl bromides had given in moderate to good yields.
► It was demonstrated that direct arylation of deficient furan can take place.