کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1322530 977213 2011 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Adding diversity to ruthenium(II)–arene anticancer (RAPTA) compounds via click chemistry: The influence of hydrophobic chains
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
Adding diversity to ruthenium(II)–arene anticancer (RAPTA) compounds via click chemistry: The influence of hydrophobic chains
چکیده انگلیسی

The application of click chemistry to develop libraries of organometallic ruthenium–arene complexes with potential anticancer properties has been investigated. A series of ruthenium–imidazole–triazole complexes, with hydrophobic tails, were prepared from a common precursor via click chemistry. The tail could be attached to the ligand prior to coordination to the ruthenium complex or following coordination, the former giving the product in superior yield. The complexes were screened for cytotoxicity in tumourigenic and non-tumourigenic cell lines, and while the compounds were only moderately cytotoxic, good selectivity for tumourigenic cells was observed.

Click chemistry was used to prepare a series of organometallic ruthenium–arene complexes with hydrophobic tails that display high selectivity and moderate anticancer activity in vitro.Figure optionsDownload as PowerPoint slideResearch highlights
► The application of click chemistry to generate collections of ruthenium-arene compounds.
► Evaluation of the anticancer properties of the compounds in vitro
► Studies into the mode of action of the compounds.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Organometallic Chemistry - Volume 696, Issue 3, 1 February 2011, Pages 772–779
نویسندگان
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