کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1322866 | 977252 | 2009 | 6 صفحه PDF | دانلود رایگان |
The methylation reaction of arsenic trioxide conducted at 37 °C and pH 7.0 for 24 h using hydrophobic methylated vitamin B12, (methyl) (aquo) heptamethylcobyrinate perchlorate, CH3B12 ester, as a methyl donor in the presence of reduced glutathione (GSH) yielded monomethylarsonous acid (MMA), dimethylarsinic acid (DMA), and trimethylarsine oxide (TMAO) as products with a methylation rate over 95%. In contrast, when methylcobalamin (CH3B12) was used as the methyl donor, only MMA and DMA were produced and the methylation rate dropped to around 20%. Reductive demethylation of a methyl-corrinoid coordination complex mediated by GSH is suggested as a mechanism of methyl transfer to arsenic trioxide. The differences observed for different corrinoid coordination complexes with respect to the reactivity of methyl transfer to arsenic is ascribable to differences inherent in the base-on (CH3B12) and base-off (CH3B12 ester) natures of the compounds.
Hydrophobic vitamin B12 derivative as methyl donor for the methylation of arsenic trioxide and glutathione gave a >95% rate of methylation at 37 °C and pH 7.0, products included monomethylarsonous acid (MMA), dimethylarsinic acid (DMA) and trimethylarsine oxide, while for methylcobalamin, the methylation rate was about 20% and only MMA and DMA were formed.Figure optionsDownload as PowerPoint slide
Journal: Journal of Organometallic Chemistry - Volume 694, Issue 6, 15 March 2009, Pages 916–921