کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1322869 | 977252 | 2009 | 5 صفحه PDF | دانلود رایگان |
2,2′-Dipyridylamine (dpa) derivatives carrying a thiol-targeted maleimide group located at the end of an alkyl substituent on the central amine were synthesized. Reaction with the organometallic precursors [(η6-arene)RuCl2]2 (arene = benzene or p-cymene) yielded the half-sandwich cationic complexes [(η6-arene)Ru(dpa)Cl]+ where the dipyridylamine derivatives were coordinated as bidentate N,N donor ligands. Enzymatic studies showed that these derivatives were able to inactivate the cysteine endoproteinase papain by S-alkylation of the cysteine active site.
2,2′-Dipyridylamine (dpa) derivatives carrying a thiol-targeted maleimide group were synthesized. Reaction with [(η6-arene)RuCl2]2 (arene = benzene or p-cymene) yielded the [(η6-arene)Ru(dpa)Cl]+ complexes where the dipyridylamine derivatives were coordinated as bidentate ligands. Enzymatic studies showed that these derivatives were able to inactivate papain by S-alkylation of its active site cysteine.Figure optionsDownload as PowerPoint slide
Journal: Journal of Organometallic Chemistry - Volume 694, Issue 6, 15 March 2009, Pages 937–941