کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1323031 | 1499838 | 2016 | 7 صفحه PDF | دانلود رایگان |
• A series of arene ruthenium compounds containing keto-amine bidentate ligands were synthesized.
• Potential anti-cancer activity of ruthenium derivatives against human hormone-refractory metastatic prostate cancer (HRMPC) cell lines.
• The ruthenium derivatives catalyzed the conversion rate in transfer hydrogenation of substituted acetophenone.
A series of keto-amine bidentate precursors 1–5, OCCH3CHCCH3NHR (where 1, R = C6H3-2,6-iPr2; 2, R = C6H2-2,4,6-Me3; 3, R = C6H4-2-tBu; 4, R = C6H4-2-OMe; 5, R = C6H4-2-OMe-5-Me) were synthesized and combined with [Ru(ɳ6-p-cymene)Cl2]2 to generate the monomeric arene-Ru derivatives, [Ru(ɳ6-p-cymene)(OCCH3CHCCH3NR)Cl] (where 6, R = C6H3-2,6-iPr2; 7, R = C6H2-2,4,6-Me3; 8, R = C6H4-2-tBu; 9, R = C6H4-2-OMe; 10, R = C6H4-2-OMe-5-Me) in moderate yield. The ruthenium derivatives effectively catalyzed the conversion rate in transfer hydrogenation of substituted acetophenone. The molecular structures of 2, 6–10 were determined by single crystal X-ray diffractometry in the solid state, revealing a four-coordination environment around the Ru atom. The potential anti-cancer activity of ruthenium derivatives against human hormone-refractory metastatic prostate cancer (HRMPC) cell lines was also studied.
A series of ruthenium compounds containing keto-amine bidentate ligands were synthesized and their potential anti-cancer activity and transfer hydrogenation activity were also studied.Figure optionsDownload as PowerPoint slide
Journal: Journal of Organometallic Chemistry - Volume 807, 1 April 2016, Pages 22–28