Synthesis and evaluation of functionalized aminobenzoboroxoles as potential anti-cancer agents

• We have prepared functionalized benzoboroxoles via reductive amination protocol.
• We have also prepared N-nitrosoaminobenzoboroxoles and benzoboroxolylureas.
• These benzoboroxoles have been further evaluated as potential anti-cancer agents.

Several aminobenzoboroxole derivatives have been prepared starting from o-boronobenzaldehyde employing reductive amination protocol. The corresponding aminobenzoboroxole derivatives have been further functionalized as N-nitrosoaminobenzoboroxoles as well as N-benzoboroxolylureas. These derivatives have been evaluated for their anti-cancer activity on human pancreatic cancer MIAPaCa-2 and human breast cancer MDA-MB-231 cell lines. 2015 Elsevier Ltd. All rights reserved.

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