The influence of N-heterocyclic carbene steric and electronic properties in Ru-catalysed cross metathesis reactions

The present study examines the influence of N-heterocyclic carbene (NHC) ligand electronic and steric parameters on the activity of ruthenium indenylidene complexes in cross metathesis. The NHC ligands tested lead to varied E/Z selectivities with the pre-catalyst bearing an IMes ligand exhibiting high activity.

The influence of N-heterocyclic carbene (NHC) ligand steric and electronic properties on the activity and E/Z selectivity of ruthenium indenylidene complexes is examined in cross metathesis reactions.Figure optionsDownload as PowerPoint slideHighlights
► We examine reactivity of a series of Ruthenium complexes in cross metathesis reactions.
► We examine the role of the supporting N-heterocyclic carbene ligand on reactivity.
► We examine the role of the supporting N-heterocyclic carbene ligand on E/Z selectivity.
► Ligand steric factors are not the only property dictating e/Z selectivity.
► The nature of the leaving group appears to also play a role on selectivity.