کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1323764 | 1499950 | 2006 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis of model BC bicycles of taxol using C10–C11 ring-closing metathesis strategy
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی معدنی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis of model BC bicycles of taxol using C10–C11 ring-closing metathesis strategy Synthesis of model BC bicycles of taxol using C10–C11 ring-closing metathesis strategy](/preview/png/1323764.png)
چکیده انگلیسی
Model BC ring-systems of taxol 23b and 28b, which lack an oxygenated substituent at C7, have been efficiently synthesized. The key step is a ring-closing metathesis (RCM) to form the 8-membered B ring between C10 and C11. Comparison of the metathesis reaction in this route with the RCM used in a previous study with similar substrates is highlighted.
Model BC ring-systems of taxol have been synthesized by ring-closing metathesis (RCM). The influence of the stereochemistry and the protecting groups of the diol moiety on the formation of the eight-membered ring has been studied. Comparison with the RCM used on similar substrates in a previous route is presented.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Organometallic Chemistry - Volume 691, Issues 24–25, 1 December 2006, Pages 5438–5443
Journal: Journal of Organometallic Chemistry - Volume 691, Issues 24–25, 1 December 2006, Pages 5438–5443
نویسندگان
Stéphanie Schiltz, Cong Ma, Louis Ricard, Joëlle Prunet,