Synthesis, spectroscopy, X-ray analysis and in vitro antiproliferative effect of ferrocenylmethylene-hydrazinylpyridazin-3(2H)-ones and related ferroceno[d]pyridazin-1(2H)-ones

Synthesis, structure determination and in vitro anticancer evaluation of novel ferrocene-based pyridazinyl hydrazones and related ferroceno-fused derivatives are reported. A planar chiral ferroceno[d]pyridazinone carrying an additional heterocyclic fragment was found to be the most promising model.