کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1323894 | 1499873 | 2014 | 6 صفحه PDF | دانلود رایگان |
• Several chiral amino diol tridentate ligands show good enantioselectivities.
• Increase in the bulkiness of the achiral auxiliary of ligands increased the enantioselectivity.
• The 1H NMR spectrum reveal the formation of mono-metallic and hexa-coordinated titanium complex.
Several highly modular chiral amino diol tridentate ligands were found to be effective for the asymmetric alkylation reaction of aromatic aldehydes in the presence of methyllithium reagent, providing up to 96% ee values and up to 94% yields under relatively mild conditions. The investigation of the catalytic activity of these ligands shows a correlation of enantioselectivities of ligands with steric properties of substituent N-alkyl and nucleophilic Li-alkyl. With the addition of Ti(O-i-Pr)4 to the ligand 3c, the 1H NMR spectrum reveals a hexa-coordinate Ti transition state complex with only one Ti metal center generated in solution.
Several highly modular chiral amino diol tridentate ligands were found to be effective for the asymmetric alkylation reaction of aromatic aldehydes in the presence of methyllithium reagent, providing up to 96% ee values and up to 94% yields under relatively mild conditions.Figure optionsDownload as PowerPoint slide
Journal: Journal of Organometallic Chemistry - Volume 768, 1 October 2014, Pages 50–55