کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1324297 | 1499889 | 2014 | 5 صفحه PDF | دانلود رایگان |
• An Au(I)-NHC-catalyzed process for benzo[b][1,4]diazepines was developed.
• 1-Substituted benzo[b][1,4]diazepines were efficiently prepared.
• Fused tricyclic benzo[b][1,4]diazepines were accessed for the first time.
1-Substituted benzo[b][1,4]diazepines which are difficult to synthesize by traditional methods have been prepared by an Au(I)–N-heterocyclic carbene complex-catalyzed tandem hydroamination/cyclization process. This protocol features the one-pot formation of a seven-membered N-heterocycle via atom-economic hydroamination/cyclization reactions of readily available N-substituted o-phenylenediamines and terminal alkynes. Based on this strategy, fused tricyclic benzo[b][1,4]diazepines have been accessed for the first time.
1-Substituted and fused polycyclic benzo[b][1,4]diazepines which are difficult to be accessed previously have been synthesized by Au(I)–NHC complex-catalyzed tandem hydroamination/cyclization protocol.Figure optionsDownload as PowerPoint slide
Journal: Journal of Organometallic Chemistry - Volume 751, 1 February 2014, Pages 438–442