کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1324610 977349 2011 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evaluation of bactericidal and fungicidal activity of ferrocenyl or phenyl derivatives in the diphenyl butene series
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
Evaluation of bactericidal and fungicidal activity of ferrocenyl or phenyl derivatives in the diphenyl butene series
چکیده انگلیسی

Some ferrocene compounds, such as tamoxifen derivatives hydroxyferrocifen 1 and ferrociphenol 2, show strong antiproliferative activity on hormone-dependent and hormone-independent breast cancer cells. In order to evaluate their antimicrobial activity, they were tested, together with their purely organic analogs, on the bacteria Pseudomonas aeruginosa and Staphylococcus aureus and the fungus Candida albicans. It has been found that the compounds bearing alkylamino chains are active, and in these cases the antimicrobial activity increases for compounds bearing two amino chains. These dialkyamino compounds are equally as active as doxycycline on P. aeruginosa and S. aureus but superior to it on C. albicans. The results show that there are no general correlation between the antitumoral activity and the bactericidal and fungicidal activities of these compounds. The ferrocene derivatives and their organic analogs have similar activity on bacteria and fungus. This bactericidal and fungicidal behaviour is a novel area of activity for these entities.

Phenyl and ferrocene compounds bearing alkylamino chains, in the tamoxifen and ferrocifen series, were found to be as active as the antibiotic doxycycline on Pseudomonas aeruginosa, Staphylococcus aureus and Candida albicans.Figure optionsDownload as PowerPoint slideResearch highlights
► Synthesis of ferrocenyl and phenyl butene derivatives.
► Antimicrobial activities are studied and compared to antiproliferative effect.
► Dialkyl amino compounds are equally as active as doxycycline.
► There is no general correlation between antitumoral and antimicrobial activities.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Organometallic Chemistry - Volume 696, Issue 5, 1 March 2011, Pages 1038–1048
نویسندگان
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