کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1324613 | 977349 | 2011 | 6 صفحه PDF | دانلود رایگان |
Bis(1,3-dimethylimidazol-2-ylidene)silver(I) nitrate and bis(4,5-dichloro-1,3-dimethylimidazol-2-ylidene)silver(I) nitrate were prepared by reacting the corresponding imidazolium nitrate salts with silver oxide. Bis(1,3-dimethylimidazol-2-ylidene)gold(I) nitrate and bis(4,5-dichloro-1,3-dimethylimidazol-2-ylidene)gold(I) nitrate salts were prepared via transmetallation of their silver precursors with chloro dimethylsulfide gold. The anticancer properties were determined using NCI-H460 lung cancer cells. Efficacy was established by comparison of the gold and silver compounds with cisplatin.
Two silver(I)-N-heterocyclic carbene (NHC) complexes were prepared by reacting corresponding imidazolium nitrate salts with silver oxide. Two gold(I)-NHC compounds were prepared via transmetallation of their silver precursors with chloro dimethylsulfide gold. Anticancer properties were determined using NCI-H460 lung cancer cells. Efficacy was established by comparison of the compounds with cisplatin.Figure optionsDownload as PowerPoint slideResearch highlights
► Synthesis of two silver(I) N-heterocyclic carbene complexes.
► Synthesis of two gold(I) N-heterocyclic carbene complexes.
► Anticancer activity of test compounds against H460 lung cancer cells.
► Efficacy not superior to cisplatin.
Journal: Journal of Organometallic Chemistry - Volume 696, Issue 5, 1 March 2011, Pages 1066–1071