Nickel-catalyzed, base-mediated amination/hydroamination reaction sequence for a modular synthesis of indoles

A catalytic system consisting of [Ni(cod)2] and ligand dppf enabled an efficient synthesis of differently substituted indoles through a modular reaction sequence, which consists of intermolecular aminations and intramolecular hydroaminations with ortho-alkynylhaloarenes.

A catalytic system consisting of [Ni(cod)2] and ligand dppf enabled an efficient synthesis of differently substituted indoles through a modular reaction sequence, which consists of intermolecular aminations and intramolecular hydroaminations with ortho-alkynylhaloarenes.Figure optionsDownload as PowerPoint slideResearch Highlights
► Nickel-catalyzed intermolecular aminations of aryl halides.
► Intramolecular hydroamination of alkynes.
► Aryl- and alkyl-substituted amines are viable substrates.