FeCl3-catalyzed addition of nitrogen and 1,3-dicarbonyl nucleophiles to olefins

A direct intermolecular addition of nitrogen and 1,3-dicarbonyl nucleophiles to stabilized double bonds (styrenes, 1,3-dienes, enol-ethers, sugars.) in the presence of green and inexpensive FeCl3 catalyst is described.

Direct intermolecular addition of nitrogen and 1,3-dicarbonyl nucleophiles to stabilized double bonds (styrenes, 1,3-dienes, enol-ethers, sugars.) in the presence of green and inexpensive FeCl3 catalyst.Figure optionsDownload as PowerPoint slideResearch highlights
► FeCl3 is a cheap, abundant and non-toxic complex.
► Hydroaminations ( and additions of 1,3-dicarbonyl nucleophiles) are 100% atom-economic reactions.
► Electronic effects in the hydroamination are highlighted.