Gold(I)-catalyzed enantioselective intramolecular hydroamination of allenes with ureas

Enantioselective intramolecular hydroamination of N-allenyl ureas catalyzed by an enantiomerically enriched bis(gold) phosphine complex forms pyrrolidine derivatives in good yield with up to 93% ee.

Enantioselective intramolecular hydroamination of N-γ-allenyl ureas catalyzed by an enantiomerically enriched bis(gold) phosphine complex forms pyrrolidine derivatives in good yield with up to 93% ee.Figure optionsDownload as PowerPoint slideResearch highlights
► Bis(gold) phosphine complex catalyzes the enantioselective hydroamination of N-allenyl ureas.
► Enantioselectivities of up to 93% ee were obtained.
► Enantioselectivity depended strongly on backbone substitution.
► Axially chiral allenes underwent hydroamination via a catalyst-controlled pathway.