کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1325040 | 977367 | 2007 | 6 صفحه PDF | دانلود رایگان |

Aminoferrocene, H2N–Fc, has been substituted to the C-terminus of six amino acids using the HBTU/HOBt coupling protocol. The synthesized bioconjugates Boc-Aaa-NH-Fc, Aaa = Gly (1), Leu (2), Phe (3), Val (4), Cys(Acm) (5), Tyr(tBu) (6) (Acm = acetamidomethyl, tBu = tert-butyl), have been characterized by 1H NMR, 13C NMR, EI-MS, EI-HRMS, UV and CD spectroscopies. In addition, a VT NMR study on 4 and the X-ray structure of 1 are presented.
The first amino acid derivatives of aminoferrocene are reported. Six derivatives with different R groups, derived from naturally occurring amino acids were prepared. The glycine derivative has been structurally characterized and hydrogen bonding interactions were investigated by CD and NMR spectroscopy.Figure optionsDownload as PowerPoint slide
Journal: Journal of Organometallic Chemistry - Volume 692, Issue 20, 15 September 2007, Pages 4209–4214