کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1325040 977367 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and structural characterization of metallated bioconjugates: C-terminal labeling of amino acids with aminoferrocene
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
Synthesis and structural characterization of metallated bioconjugates: C-terminal labeling of amino acids with aminoferrocene
چکیده انگلیسی

Aminoferrocene, H2N–Fc, has been substituted to the C-terminus of six amino acids using the HBTU/HOBt coupling protocol. The synthesized bioconjugates Boc-Aaa-NH-Fc, Aaa = Gly (1), Leu (2), Phe (3), Val (4), Cys(Acm) (5), Tyr(tBu) (6) (Acm = acetamidomethyl, tBu = tert-butyl), have been characterized by 1H NMR, 13C NMR, EI-MS, EI-HRMS, UV and CD spectroscopies. In addition, a VT NMR study on 4 and the X-ray structure of 1 are presented.

The first amino acid derivatives of aminoferrocene are reported. Six derivatives with different R groups, derived from naturally occurring amino acids were prepared. The glycine derivative has been structurally characterized and hydrogen bonding interactions were investigated by CD and NMR spectroscopy.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Organometallic Chemistry - Volume 692, Issue 20, 15 September 2007, Pages 4209–4214
نویسندگان
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