کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1325561 1499880 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Di- and tri-organotin(IV) complexes of arylhydrazones of methylene active compounds and their antiproliferative activity
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
Di- and tri-organotin(IV) complexes of arylhydrazones of methylene active compounds and their antiproliferative activity
چکیده انگلیسی


• Mono- and tetranuclear organotin(IV) compounds derived from arylhydrazones of acetylacetone and barbituric acid.
• The organotin complexes exhibit antitumor activity in vitro.
• The organotin complexes are combined in a 3D supramolecular framework.

Two organotin(IV) complexes, [Sn(C6H5)3HL1] (1) and [Sn(C2H5)2(1κO,2κO-H3L2)(1κO2-H3L2)(μ3-O)]2 (2), were isolated upon interaction of Ph3SnCl and Et2SnO with 2-(2-(2,4-dioxopentan-3-ylidene)hydrazinyl)benzoic acid (H2L1) and 2-(2-(2,4,6-trioxotetrahydropyrimidin-5(2H)-ylidene) hydrazinyl)benzoic acid (H4L2), respectively, in toluene solution. Complexes 1 and 2 were characterized by IR and NMR spectroscopies, elemental and single crystal X-ray diffraction analyses. While in 1 the (HL1)– ligand binds the metal in a chelating bidentate mode, in 2 the (H3L2)– anion acts not only as a chelating bidentate but also as a bridging bidentate donor. The in vitro antiproliferative activity against human colorectal carcinoma (HCT116) and human hepatocellular carcinoma (HEPG2) cells lines demonstrated that compound 1 possesses high in vitro antiproliferative activity with IC50 values of 0.0284 ± 0.0001 μM and 0.287 ± 0.0001 μM for HCT116 and HEPG2 cells, respectively.

New organotin(IV) complexes exhibit high in vitro antiproliferative activity against human colorectal and hepatocellular carcinoma cells lines.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Organometallic Chemistry - Volume 760, 15 June 2014, Pages 67–73
نویسندگان
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