Nickel-catalyzed hydrodehalogenation of aryl halides

In the present study, the nickel-catalyzed dehalogenation of aryl and alkyl halides with iso-propyl zinc bromide or tert-butylmagnesium chloride has been examined in detail. With a straightforward nickel complex as pre-catalyst good to excellent yields and chemoselectivities were feasible for a variety of aryl and alkyl halides.

In the present study, the nickel-catalyzed dehalogenation of aryl and alkyl halides with iso-propyl zinc bromide or tert-butylmagnesium chloride has been examined in detail. With a straightforward nickel complex as pre-catalyst good to excellent yields and chemoselectivities were feasible for a variety of aryl and alkyl halides.Figure optionsDownload as PowerPoint slideHighlights
► A novel nickel complex modified by a O, N, O ligand was synthesized.
► The nickel complex was applied as pre-catalyst in the hydrodehalogenation of aryl and alkyl halides.
► Good to excellent yields and chemoselectivities were feasible.