Ruthenium-catalyzed tandem ring closing metathesis (RCM) – atom transfer radical cyclization (ATRC) sequences

α-ω-Dienes bearing a pendant trichloroacetoxy group undergo a tandem RCM – radical cycloisomerization sequence leading to bicyclic γ-butyrolactones, with both steps of the sequence being catalyzed by ruthenium.

A sequential ring closing metathesis-radical cyclization reaction is described that proceeds in one pot using only one precatalyst.Figure optionsDownload as PowerPoint slide