Enantioselective catalytic allylation of arylmethylketones using tetraallyltin and tin(IV) chloride mixtures

Reaction of SnCl4 with Sn(CH2CHCH2)4 in the presence of water and monothiobinaphthol [2,2′-C20H12(OH)(SH)] allows the formation of a selective catalyst for the allylation of ketones (up to 94% e.e.).

Use of Sn(allyl)4/SnCl4 mixtures allows rapid access to a selective asymmetric allylation catalyst.Figure optionsDownload as PowerPoint slide