کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1327167 977465 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Chemical and biotechnological developments in organotin cancer chemotherapy
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
Chemical and biotechnological developments in organotin cancer chemotherapy
چکیده انگلیسی

This review provides a substantial knowledge on the action mode of organotins in cancer chemotherapy. The coordinating ability of organotin compounds towards DNA and cancer cells is discussed. Most of the organotins tested are DNA-targeted and mitotic, the action mode occurring via a gene-mediated pathway. These potential anti-cancer drugs are actually being studied widely, and whilst they are efficacious and perhaps curative against a select number of neoplasias, suffer from a variety of deficiencies, notably severe systemic toxicity and a tendency to elicit drug resistance.

A brief report on organotin cancer chemotherapy (in vivo and in vitro), with particular emphasis to the gene mediated mechanistic pathway of drug interactions and molecular biology.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Organometallic Chemistry - Volume 691, Issue 8, 1 April 2006, Pages 1761–1766
نویسندگان
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