کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1327205 977469 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Organotin(IV) 4-nitrophenylethanoates: Synthesis, structural characteristics and intercalative mode of interaction with DNA
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
Organotin(IV) 4-nitrophenylethanoates: Synthesis, structural characteristics and intercalative mode of interaction with DNA
چکیده انگلیسی

Four new organotin(IV) carboxylates, [Bu2SnL2] (1), [Et2SnL2] (2), [Bu3SnL]n(3), [Me3SnL]n(4), where L = 4-nitrophenylethanoates, were synthesized and characterized by elemental analysis, FT-IR and multinuclear NMR (1H and 13C). Spectroscopic results authenticated the coordination of ligand to the organotin moiety via COO group while X-ray single crystal analysis revealed bidentate chelating mode of coordination of ligand in complex 2 and a bridging behavior in complexes 3 and 4. Cyclic voltammetric (CV) technique was used to evaluate the electrochemical, kinetic and thermodynamic parameters of complexes 1-4, interacting with DNA. The linearity of the plots between the peak current (I) and the square root of the scan rate (ν1/2) indicated the electrochemical processes to be diffusion controlled. The diffusion coefficients of the free (Df) and DNA bound forms (Db), standard rate constants (ks) and charge transfer coefficients (α) were determined by the application of Randle–Sevcik, Nicholson and Kochi equations. Furthermore, the binding constants evaluated from voltammetric data revealed the following increasing order of binding strength: 2 < 1 < 4 < 3. For 1 and 2, the activity against prostate cancer cell lines (PC-3) was found consistent with the order obtained from voltammetric behavior.

Four novel Organotin(IV) complexes of 4-Nitrophenyl ethanoic acid have been synthesized, and characterized by elemental analysis FT-IR, multinuclear NMR (1H, 13C) and X-ray single crystal analysis. Cyclic voltammetric technique was used to evaluate the electrochemical, kinetic and thermodynamic parameters of these complexes interacting with DNA.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Organometallic Chemistry - Volume 694, Issue 21, 1 October 2009, Pages 3431–3437
نویسندگان
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