کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1328248 | 977554 | 2007 | 5 صفحه PDF | دانلود رایگان |

We review our recent results on the rhodium-catalyzed hydroformylation of chiral and prochiral N-allylpyrroles as a synthetic route to stereodefined 5,6-dihydro- and 5,6,7,8-tetrahydroindolizines. The indolizine nucleus at different degrees of unsaturation is a building block of natural and synthetic target compounds; thus new approaches, especially if stereoselective and/or stereospecific, are highly desirable. The construction of the indolizine architectures reported here occurs by formation of a C8–C9 bond through intramolecular cyclization of the 4-pyrrolylbutanal intermediate.
A short review is given on the rhodium-catalyzed hydroformylation of chiral and prochiral N-allylpyrroles as a synthetic route to stereodefined 5,6-dihydro- and 5,6,7,8-tetrahydroindolizines. In the key step, the carbonyl group of a 4-pyrrolylbutanal, the oxo product, becomes the starting point for an intramolecular cyclization reaction generating the C8–C9 indolizine bond.Figure optionsDownload as PowerPoint slide
Journal: Journal of Organometallic Chemistry - Volume 692, Issue 9, 1 April 2007, Pages 1812–1816