Thermodynamic and spectroscopic study of the interaction of Cu(II), Ni(II), Zn(II) and Ca(II) ions with 2-amino-N-(2-oxo-2-(2-(pyridin-2-yl)ethyl amino)ethyl)acetamide, a pseudo-mimic of human serum albumin

Solution speciation of Cu(II), Ca(II), Zn(II) and Ni(II) complexes of a mixed amino/amido/pyridyl ligand is reported. The ligand is able to promote dermal absorption and mobilize Cu(II) in vivo.