کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
13412199 1841099 2019 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mnemonic Similarity Task: A Tool for Assessing Hippocampal Integrity
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب شناختی
پیش نمایش صفحه اول مقاله
Mnemonic Similarity Task: A Tool for Assessing Hippocampal Integrity
چکیده انگلیسی
The hippocampus is critical for learning and memory, relying in part on pattern separation processes supported by the dentate gyrus (DG) to prevent interference from overlapping memory representations. In 2007, we designed the Mnemonic Similarity Task (MST), a modified object recognition memory task, to be highly sensitive to hippocampal function by placing strong demands on pattern separation. The MST is now a widely used behavioral task, repeatedly shown to be sensitive to age-related memory decline, hippocampal connectivity, and hippocampal function, with specificity to the DG. Here, we review the utility of the MST, its relationship to hippocampal function, its utility in detecting hippocampal-based memory alterations across the lifespan, and impairments associated with clinical pathology from a variety of disorders.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Trends in Cognitive Sciences - Volume 23, Issue 11, November 2019, Pages 938-951
نویسندگان
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