کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
13472765 | 1846519 | 2020 | 21 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Biogenic platinum nanoparticles using black cumin seed and their potential usage as antimicrobial and anticancer agent
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
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چکیده انگلیسی
Herein, the biogenic platinum nanoparticles (Pt NPs) were synthesized by using black cumin seed (Nigella sativa L.) extract as a reducing agent. The biogenic platinum nanoparticles synthesized by black cumin seed extract was characterized in detail by Transmission Electron Microscopy (TEM), UV-vis spectrophotometer, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS). According to TEM analysis, Pt nanoparticles have spherical shapes and sizes between 1-6â¯nm. Moreover, the biogenic Pt NPs was assessed for its cytotoxicity effect on MDA-MB-231 breast and HeLa cervical cancer lines and their antibacterial effect against selected strains of gram-positive and negative bacteria. The cytotoxicity and bacterial tests showed the effectiveness of biogenic Pt nanoparticles. Dose-dependent toxicity effects were shown in the MDA-MB-231 breast and HeLa cervical cancer lines (IC50: 36.86â¯Î¼g/mL and 19.83â¯Î¼g/mL, respectively). In addition, Pt NPs showed high zone diameters against gram-positive and gram-negative bacteria at concentrations of 100 and 500â¯Î¼g/ml. These results contribute to the development of the pharmaceutical industry as a potential antibacterial and anticancer agent.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 179, 5 February 2020, 112961
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 179, 5 February 2020, 112961
نویسندگان
Aysenur Aygun, Fulya Gülbagca, Lutfiye Yildiz Ozer, Buket Ustaoglu, Yasemin Celik Altunoglu, Mehmet Cengiz Baloglu, Mehmet Nuri Atalar, Mehmet Hakkı Alma, Fatih Sen,