کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1355373 | 980853 | 2007 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mechanistic differences between in vitro assays for hydrazone-based small molecule inhibitors of anthrax lethal factor
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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![عکس صفحه اول مقاله: Mechanistic differences between in vitro assays for hydrazone-based small molecule inhibitors of anthrax lethal factor Mechanistic differences between in vitro assays for hydrazone-based small molecule inhibitors of anthrax lethal factor](/preview/png/1355373.png)
چکیده انگلیسی
A systematically generated series of hydrazones were analyzed as potential inhibitors of anthrax lethal factor. The hydrazones were screened using one UV-based and two fluorescence-based in vitro assays. The study identified several inhibitors with IC50 values in the micromolar range, and importantly, significant differences in the types of inhibition were observed with the different assays.
Structure–activity study of hydrazones as inhibitors of anthrax lethal factor using three in vitro assays.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic Chemistry - Volume 35, Issue 1, February 2007, Pages 50–58
Journal: Bioorganic Chemistry - Volume 35, Issue 1, February 2007, Pages 50–58
نویسندگان
M. Leslie Hanna, Theodore M. Tarasow, Julie Perkins,