کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1355620 | 1500456 | 2015 | 13 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Synthesis, molecular docking and anti-inflammatory screening of novel quinoline incorporated pyrazole derivatives using the Pfitzinger reaction II Synthesis, molecular docking and anti-inflammatory screening of novel quinoline incorporated pyrazole derivatives using the Pfitzinger reaction II](/preview/png/1355620.png)
• New quinolines incorporated pyrazoles were synthesized.
• Screening of anti-inflammatory, analgesic, and ulcerogenic activities were performed for the synthesized compounds.
• Molecular modeling study was performed for compounds (5–11).
In continuation of our study of novel quinolines with anti-inflammatory activity using the Pfitzinger reaction, several new quinoline derivatives were synthesized and tested for their anti-inflammatory and ulcerogenic effect. A docking study on the COX-2 binding pocket was carried out for the target compounds to rationalize the possible selectivity of them against COX-2 enzyme. The most active compounds (5a, 8a and 11a) were found to be superior to celecoxib. Compound 11a demonstrated the highest anti-inflammatory activity as well as the best binding profiles into the COX-2 binding site. Moreover, compounds 9c, 9e, 10a and 11a were devoid of ulcerogenic activity.
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Journal: Bioorganic Chemistry - Volume 58, February 2015, Pages 104–116