کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1355633 1500461 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Development of novel pyrazolone derivatives as inhibitors of aldose reductase: An eco-friendly one-pot synthesis, experimental screening and in silico analysis
ترجمه فارسی عنوان
توسعه مشتقات جدید پیرازولون به عنوان مهار کننده های آلدووزید ردوکتاز: یک سنتز یک گلدان سازگار با محیط زیست، غربالگری تجربی و در تجزیه و تحلیل سیلیکا
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی


• Synthesis of novel pyrazolone and pyrazole-carbothioamide derivatives.
• In vitro testing of derivatives for aldose reductase inhibition.
• Docking and paired potential analysis of novel derivatives.
• Structure activity relationship between in vitro results using in silico method.

Aldose reductase is the key enzyme of polypol pathway leading to accumulation of sorbitol. Sorbitol does not diffuse across the cell membranes easily and therefore accumulates within the cell, causing osmotic damage which leads to retinopathy (cataractogenesis), neuropathy and other diabetic complications. Currently, aldose reductase inhibitors like epalrestat, ranirestat and fidarestat are used for the amelioration of diabetic complications. However, such drugs are effective in patients having good glycemic control and less severe diabetic complications. In present study we have designed novel pyrazolone derivative and performed eco-friendly synthesis approach and tested the synthesized compounds as potential inhibitors of aldose reductase activity. Additional in silico analysis in current study indicates presence of highly conserved chemical environment in active site of goat lens aldose reductase. The reported data is expected to be useful for developing novel pyrazolone derivatives as lead compounds in the management of diabetic complications.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic Chemistry - Volume 53, April 2014, Pages 67–74
نویسندگان
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