کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1355656 1500471 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Structures, mechanisms and inhibitors of undecaprenyl diphosphate synthase: A cis-prenyltransferase for bacterial peptidoglycan biosynthesis
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Structures, mechanisms and inhibitors of undecaprenyl diphosphate synthase: A cis-prenyltransferase for bacterial peptidoglycan biosynthesis
چکیده انگلیسی

Isoprenoids are an intensive group of compounds made from isopentenyl diphosphate (IPP), catalyzed by prenyltransferases such as farnesyl diphosphate (FPP) cyclases, squalene synthase, protein farnesyltransferases and geranylgeranyltransferases, aromatic prenyltransferases as well as a group of prenyltransferases (cis- and trans-types) catalyzing consecutive condensation reactions of FPP with specific numbers of IPP to generate linear products with designate chain lengths. These prenyltransferases play significant biological functions and some of them are drug targets. In this review, structures, mechanisms, and inhibitors of a cis-prenyltransferase, undecaprenyl diphosphate synthase (UPPS) that mediates bacterial peptidoglycan biosynthesis, are summarized for comparison with the most related trans-prenyltransferases and other prenyltransferases.

Figure optionsDownload as PowerPoint slideHighlights
► Complete kinetic scheme of UPPS reaction is illustrated.
► Product dissociation rate constants are displayed.
► Conformational changes during catalysis of UPPS are demonstrated.
► Intermediate in each IPP condensation of UPPS reaction and the mechanism are described.
► Inhibitors of UPPS are shown.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic Chemistry - Volume 43, August 2012, Pages 51–57
نویسندگان
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