Structure–activity relationships in new polycationic molecules based on two 1,4-diazabicyclo[2.2.2]octanes as artificial ribonucleases

• A novel series of DABCO based artificial ribonucleases was synthesised.
• The linker moiety plays a key role in RNA cleavage by DABCO-contained aRNases.
• The hydrophobic groups are an important requirement for the aRNase activity.
• Compound 18 displayed the best cleavage activity.

In the present study, we designed and synthesised new polycationic molecules based on two 1,4-diazabicyclo[2.2.2]octane (DABCO) moieties with hydrophobic groups connected by different linkers. The structure and the RNA-cleavage activity relationships of this novel series of artificial ribonucleases (aRNases) were investigated.

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