کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1355965 | 981079 | 2007 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Carbanions from decarboxylation of orotate analogs: Stability and mechanistic implications Carbanions from decarboxylation of orotate analogs: Stability and mechanistic implications](/preview/png/1355965.png)
The pKa’s of the 6-CH groups of 1,3-dimethyluracil, N-methyl-2-pyridone, and N-methyl-4-pyridone were determined through their reactions with bases derived from carbon acids with known pKa and the reactions of their corresponding carbanions with the carbon acids. No correlation between the stability of the carbanions and the rate of decarboxylation of corresponding carboxylic acids was found.
The pKa’s of the 6-CH groups of 1,3-dimethyluracil, N-methyl-2-pyridone, and N-methyl-4-pyridone were determined through their reactions with bases derived from carbon acids with known pKa and the reactions of their corresponding carbanions with the carbon acids. No correlation between the stability of the carbanions and the rate of decarboxylation of corresponding carboxylic acids was found.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic Chemistry - Volume 35, Issue 4, August 2007, Pages 338–343