کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1356446 | 981119 | 2009 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis of novel phosphorothioates and phosphorodithioates and their differential inhibition of cholinesterases
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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چکیده انگلیسی
The anticholinesterase activities of newly synthesized phosphorothioates and phosphorodithioates were investigated. The compounds were evaluated for their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition potency through IC50 determination. The selectivities of the synthesized compounds toward both enzymes were determined and compared in terms of their molecular structures.
The anticholinesterase activities of newly synthesized phosphorothioates and phosphorodithioates were investigated. The compounds were evaluated for their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition potency through IC50 determination.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic Chemistry - Volume 37, Issue 4, August 2009, Pages 101–105
Journal: Bioorganic Chemistry - Volume 37, Issue 4, August 2009, Pages 101–105
نویسندگان
Babak Kaboudin, Saeed Emadi, Atefeh Hadizadeh,