کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1356446 981119 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis of novel phosphorothioates and phosphorodithioates and their differential inhibition of cholinesterases
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis of novel phosphorothioates and phosphorodithioates and their differential inhibition of cholinesterases
چکیده انگلیسی

The anticholinesterase activities of newly synthesized phosphorothioates and phosphorodithioates were investigated. The compounds were evaluated for their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition potency through IC50 determination. The selectivities of the synthesized compounds toward both enzymes were determined and compared in terms of their molecular structures.

The anticholinesterase activities of newly synthesized phosphorothioates and phosphorodithioates were investigated. The compounds were evaluated for their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition potency through IC50 determination.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic Chemistry - Volume 37, Issue 4, August 2009, Pages 101–105
نویسندگان
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