کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1356462 | 981121 | 2009 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Antimalarial and antitrypanosomal activity of a series of amide and sulfonamide derivatives of a 2,5-diaminobenzophenone
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Antimalarial and antitrypanosomal activity of a series of amide and sulfonamide derivatives of a 2,5-diaminobenzophenone Antimalarial and antitrypanosomal activity of a series of amide and sulfonamide derivatives of a 2,5-diaminobenzophenone](/preview/png/1356462.png)
چکیده انگلیسی
Here, we describe a series of readily obtainable benzophenone derivatives with antimalarial and antitrypanosomal activity. The most active compounds display submicromolar activity against Plasmodium falciparum. Micromolar activity is obtained against Trypanosoma brucei. Main problem of the compounds is low selectivity. However, there are indications that separation of antimalarial and cytotoxic activity might by possible. In addition, some compounds inhibit human ABC transporter with nanomolar activity.
Here, we describe a series of amide and sulfonamide derivatives of 2,5-diaminobenzophenone. The most active derivative inhibits the growth of malaria parasites with an IC50 value of 110 nM.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 17, Issue 22, 15 November 2009, Pages 7690–7697
Journal: Bioorganic & Medicinal Chemistry - Volume 17, Issue 22, 15 November 2009, Pages 7690–7697
نویسندگان
Mirko Altenkämper, Benjamin Bechem, Johann Perruchon, Swetlana Heinrich, Andrea Mädel, Regina Ortmann, Hans-Martin Dahse, Ellen Freunscht, Yulin Wang, Jennifer Rath, August Stich, Manuela Hitzler, Peter Chiba, Michael Lanzer, Martin Schlitzer,