کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1356474 | 981121 | 2009 | 7 صفحه PDF | دانلود رایگان |
Bis-Schiff bases 1–27 have been synthesized and their in vitro antiglycation potential has been evaluated. Compounds 21 (IC50 = 243.95 ± 4.59 μM), 20 (IC50 = 257.61 ± 5.63 μM), and 7 (IC50 = 291.14 ± 2.53 μM) showed an excellent antiglycation activity better than the standard (rutin, IC50 = 294.46 ± 1.50 μM). This study has identified a series of potential molecules as antiglycation agents. A structure–activity relationship has been studied, and all the compounds were characterized by spectroscopic techniques.
A series of bis-Schiff bases of isatin 1–27 has been synthesized and screened for their antiglycation activity in vitro.Where R1, R2, and R3 are mono- and disubstituted chloro analogs while R4 may be substituted aryl groups.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry - Volume 17, Issue 22, 15 November 2009, Pages 7795–7801