کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1356511 | 981127 | 2009 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
NO-glibenclamide derivatives: Prototypes of a new class of nitric oxide-releasing anti-diabetic drugs
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: NO-glibenclamide derivatives: Prototypes of a new class of nitric oxide-releasing anti-diabetic drugs NO-glibenclamide derivatives: Prototypes of a new class of nitric oxide-releasing anti-diabetic drugs](/preview/png/1356511.png)
چکیده انگلیسی
Endothelial dysfunction and consequent reduction of biosynthesis of endogenous nitric oxide (NO) play an important pathogenetic role in the cardiovascular complications associated with type II diabetes. In this work, the hybrid drugs 3a and 3b, nitrooxymethylbenzoate-derivatives of 1 (which is a hydroxylated active metabolite of glibenclamide 2), are reported. The pharmacodynamic characterization of 3b showed that its hypoglycaemic activity is enriched with additional NO-donor effects, conferring vasorelaxing and anti-platelet properties of potentially great usefulness for diabetes-related cardiovascular disorders.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 17, Issue 15, 1 August 2009, Pages 5426–5432
Journal: Bioorganic & Medicinal Chemistry - Volume 17, Issue 15, 1 August 2009, Pages 5426–5432
نویسندگان
Vincenzo Calderone, Simona Rapposelli, Alma Martelli, Maria Digiacomo, Lara Testai, Scilla Torri, Piero Marchetti, Maria C. Breschi, Aldo Balsamo,