Design, synthesis and evaluation of d-galactose-β-cyclodextrin conjugates as drug-carrying molecules

Several kinds of d-galactose-β-cyclodextrin conjugates having a phenyl group in the spacers between the d-galactose and β-cyclodextrin were designed and synthesized as drug-carrying molecules. Their evaluation as drug-carrying molecules was done by measuring the molecular interactions with the anticancer agent, doxorubicin, and with the d-galactose-binding peanut lectin using an SPR optical biosensor. The SPR analyses showed that these conjugates had remarkably high inclusion associations of 105 ∼ 107 M−1 levels for the immobilized doxorubicin. Their association constants for immobilized peanut lectin were at the level of 104 ∼ 105 M−1, as we expected. These conjugates will be useful drug-carrying models which can site-specifically carry doxorubicin to the cells containing d-galactose-binding lectin.

Several kinds of d-galactose-β-cyclodextrin conjugates were designed and synthesized as drug-carrying molecules. These conjugates had remarkably high inclusion associations of 105 ∼ 107 M−1 levels for the immobilized doxorubicin.Figure optionsDownload as PowerPoint slide