Synthesis of 2,4,6-trisubstituted pyrimidine and triazine heterocycles as antileishmanial agents

A series of 2,4,6 trisubstituted pyrimidines and triazines have been synthesized and screened for its in vitro antileishmanial activity profile in promastigote model. Nine compounds have shown >94% inhibition against promastigotes at a concentration of 10 μg/mL.

A series of 2,4,6-trisubstituted pyrimidines and triazines have been synthesized and screened for its in vitro antileishmanial activity profile in promastigote model. Nine compounds have shown >94% inhibition against promastigotes at a concentration of 10 μg/mL.Figure optionsDownload as PowerPoint slide