2-Deoxy-2,3-didehydro-N-acetylneuraminic acid analogues structurally modified at the C-4 position: Synthesis and biological evaluation as inhibitors of human parainfluenza virus type 1

To explore the influence of binding to human parainfluenza virus type 1 (hPIV-1), a series of 4-O-substituted Neu5Ac2en derivatives 6a–e was synthesized and tested for their ability to inhibit hPIV-1 sialidase. Among compounds 6a–e, the 4-O-ethyl-Neu5Ac2en derivative 6b showed the most potent inhibitory activity (IC50 6.3 μM) against hPIV-1 sialidase.

Among the 4-O-substituted Neu5Ac2en derivatives 6a–e, the 4-O-ethyl-Neu5Ac2en derivative 6b showed the most potent inhibitory activity (IC50 6.3 μM) against human parainfluenza virus type 1 (hPIV-1) sialidase.Figure optionsDownload as PowerPoint slide