کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1357031 | 981189 | 2006 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cytotoxic labdane alkaloids from an ascidian Lissoclinum sp.: Isolation, structure elucidation, and structure–activity relationship
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Four labdane alkaloids, haterumaimides N–Q (1–4), were isolated from an ascidian Lissoclinum sp. and their structures were elucidated by chemical and spectral analyses. Investigation of the structure–activity relationships of haterumaimides J–K, N–Q, and 14 related compounds suggested that the presence of hydroxyl groups at C-6, C-7, C-12, and C-18, a chlorine atom at C-2, and an imido NH in ring C should be essential for cytotoxicity against P388 cells.
Four new cytotoxic labdane alkaloids, haterumaimides N–Q were isolated from the ascidian Lissoclinum sp. Their structures and SAR studies of this series of alkaloids are described.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 14, Issue 20, 15 October 2006, Pages 6954–6961
Journal: Bioorganic & Medicinal Chemistry - Volume 14, Issue 20, 15 October 2006, Pages 6954–6961
نویسندگان
Jasim Uddin, Katsuhiro Ueda, Eric R.O. Siwu, Masaki Kita, Daisuke Uemura,