Grifolin derivatives from Albatrellus caeruleoporus, new inhibitors of nitric oxide production in RAW 264.7 cells

Two new farnesyl phenols named grifolinones A and B, together with known grifolin and neogrifolin, were isolated from methanolic extract of the inedible mushroom Albatrellus caeruleoporus. Their structures were characterized by a combination of 2D NMR, MS, IR, and UV spectra. Grifolinone B was composed of two grifolin molecules, which were connected by a C–C bond. Grifolinones A and B, grifolin, and neogrifolin exhibited inhibitory activity against nitric oxide (NO) production stimulated by lipopolysaccharide (LPS) in RAW 264.7 cells with IC50 values of 23.4, 22.9, 29.0, and 23.3 μM, respectively.

Two new farnesyl phenols named grifolinones A and B, together with known grifolin and neogrifolin which exhibited the inhibitory activity of nitric oxide production stimulated by lipopolysaccharide in RAW 264.7 cells, were isolated from the fungus Albatrellus caeruleoporus.Figure optionsDownload as PowerPoint slide