N,N′-Bis(3-aminopropyl)-2,7-diamino-1,8-naphthyridine stabilized a single pyrimidine bulge in duplex DNA

We here show the first identified ligand 2,7-diamino-1,8-naphthyridine (DANP) that strongly and specifically binds to the single cytosine and thymine bulges with exclusively 1:1 stoichiometry.

A new ligand N,N′-bis(3-aminopropyl)-2,7-diamino-1,8-naphthyridine bound to cytosine and thymine bulges. CSI-TOF MS firmly confirmed the 1:1 binding stoichiometry.Figure optionsDownload as PowerPoint slide