کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1357560 981258 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The influence of halogen substituents on the biological properties of sulfur-containing flavonoids
ترجمه فارسی عنوان
تأثیر جایگزین های هالوژن بر خواص بیولوژیکی فلاونوئیدها حاوی گوگرد
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی

A series of halogen-substituted tricyclic flavonoids containing a 1,3-dithiol-2-ylium moiety has been synthesized from the corresponding 3-dithiocarbamic flavanones. The influence of halogen substituents on the antibacterial properties of the tricyclic flavonoids has been investigated against Staphylococcus aureus and Escherichia coli. On going from fluorine to iodine, these compounds exhibit good to excellent inhibitory properties against both Gram-positive and Gram-negative pathogens. These results suggest that size is the main factor for the change in potency rather than polarity/electronics.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 24, Issue 14, 15 July 2016, Pages 3166–3173
نویسندگان
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