کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1358608 | 981350 | 2012 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis of Leubethanol derivatives and evaluation against Mycobacterium tuberculosis
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Twenty-five derivatives of the natural diterpene leubethanol, including several potential pro-drugs, with changes in the functionality of the aliphatic chain or modifications of the phenolic group, were synthesized and tested in vitro by the MABA technique for their activity against the H37Rv strain of Mycobacterium tuberculosis. Several compounds showed antimycobacterial potencies similar to that of the lead compound and two of them displayed higher selectivity indexes.
Twenty-five derivatives of the natural diterpene leubethanol are described and tested against Mycobacterium tuberculosis H37Rv.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 20, Issue 13, 1 July 2012, Pages 4155–4163
Journal: Bioorganic & Medicinal Chemistry - Volume 20, Issue 13, 1 July 2012, Pages 4155–4163
نویسندگان
Jonathan Perez-Meseguer, Esther del Olmo, Blanca Alanis-Garza, Ricardo Escarcena, Elvira Garza-González, Ricardo Salazar-Aranda, Arturo San Feliciano, Noemí Waksman de Torres,